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<p class="MsoNormal"><span lang="EN-US">PhD position in Atmospheric chemistry/Ecotoxicology (2024-2027) at INERIS (France) (fully funded)<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-GB">WOODSOA-AhR</span></b><span lang="EN-GB">: Characterization of the AhR biological activity induced by primary and secondary emissions from residential wood heating combining
<i>in vitro/in vivo</i> bio-analytical approach and chemical analyses<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Aptos",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-US">Keywords</span></u><span lang="EN-US">: Air quality, Particles, Biomass burning, Reactivity, Secondary Organic Aerosols (SOA), Toxicity, Bioassays, Zebrafish.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Link here: </span><span style="font-family:"Aptos",sans-serif"><a href="https://www.ineris.fr/sites/ineris.fr/files/job_offer/2024-08/PhD%20offer%20_Characterization%20of%20biological%20activity%20emissions%20wood%20heating_vEn_vf.pdf"><span lang="EN-US">https://www.ineris.fr/sites/ineris.fr/files/job_offer/2024-08/PhD%20offer%20_Characterization%20of%20biological%20activity%20emissions%20wood%20heating_vEn_vf.pdf</span></a></span><span lang="EN-US" style="font-family:"Aptos",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Location: Verneuil-en-Halatte (60), France – accessible by public transport, 40 minutes North of Paris.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-GB">Type of contract: </span></b><span lang="EN-GB">PhD Fixed-term (2024 - 2027)<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-GB">PhD directors</span></b><span lang="EN-GB">: Alexandre Albinet (INERIS) and Barbara D’Anna (LCE - University Aix Marseille)<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-GB">Supervision</span></b><span lang="EN-GB">: Alexandre Albinet, Abd El Rahman El Mais and François Brion (INERIS)<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-GB">Contacts: </span></b><a href="mailto:alexandre.albinet@ineris.fr"><span lang="EN-GB">alexandre.albinet@ineris.fr</span></a><u><span lang="EN-GB">;
</span></u><a href="mailto:abd-el-rahman.el-mais@ineris.fr"><span lang="EN-GB">abd-el-rahman.el-mais@ineris.fr</span></a><u><span lang="EN-GB">;
</span></u><a href="mailto:francois.brion@ineris.fr"><span lang="EN-GB">francois.brion@ineris.fr</span></a><span lang="EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB">- Phone: 0344556485/6201/6512 for more information<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Thesis Location: 100% INERIS<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Desired start date: October - December 2024<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Salary: €2105 gross/month<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• 18 RTT + 31 CP annual leave<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Flexible hours<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Staff canteen<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Charging stations for electric vehicles<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Our job offer is open to all. We aim to integrate new talents into an inclusive work environment.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-US">Context and objectives<o:p></o:p></span></u></p>
<p class="MsoNormal"><span lang="EN-US" style="background:yellow;mso-highlight:yellow"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Residential wood heating significantly contributes to fine particle (PM2.5) concentrations observed in ambient air, especially during the winter. This source emits also large quantities of organic species of different
volatilities which are transformed in the atmosphere through physical and (photo-)chemical processes into secondary organic aerosols (SOA) contributing significantly to fine PM concentrations. The current understanding of the SOA formation processes from these
emissions, or from precursor molecules, as well as their physicochemical properties, is still limited, particularly for nighttime chemical processes (involving the NO3 radical) or processes under marine influence involving halogen radicals. The toxic potential
of these primary or secondary particles and the associated chemical compounds are also unknown. Toxic compounds such as polycyclic aromatic hydrocarbons (PAHs) and their nitrated or oxygenated derivatives (nitro- and oxy-PAHs) are known to be associated with
this type of particles. However, their chemical analysis does not account for all emitted PAH-like compounds, especially biologically active compounds, nor does it account for mixture effects. Methods based on specific biological effects of a toxic mode of
action (e.g., activation of the aryl hydrocarbon receptor (AhR) by PAH or dioxin-like compounds) using in vitro (cell models) or in vivo (whole organisms) assays can address these issues and are complementary to chemical analyses.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">In this context, the main objectives of this PhD thesis are to:
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Study and characterize the formation of SOA from precursors typically emitted by biomass burning (e.g., PAHs and phenolic compounds) under marine influence (involving Cl radicals).<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Quantify and compare, using cellular bioassays, the AhR biological activities (PAH- and dioxin-like) of gaseous and particulate, primary and secondary (aged) emissions from residential wood heating, and SOA
formed from PAHs and phenols, under different combustion conditions (excess/lack of air, fuel, log or pellet appliances, etc.) and oxidation simulating daytime, nighttime, and marine influence atmospheric processes (involving OH, NO3, and Cl radicals).<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Evaluate the biological effects (e.g., embryonic development, AhR activity, endocrine disruption, cardiac activity alteration) on a model organism (zebrafish embryos, Danio rerio) of organic compounds associated
with PM and determine a threshold in vitro activity value beyond which there is a danger to the organism.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Compare and study potential links between the detailed chemical characterization of gaseous and particulate phases and the in vitro/in vivo biological responses to identify the most active chemical species
towards the molecular targets studied in cell models and zebrafish embryos.<span style="background:yellow;mso-highlight:yellow"><o:p></o:p></span></span></p>
<p class="MsoNormal"><span lang="EN-US" style="background:yellow;mso-highlight:yellow"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-US">Candidate profile<o:p></o:p></span></u></p>
<p class="MsoNormal"><span lang="EN-US" style="background:yellow;mso-highlight:yellow"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Master’s degree in Environmental chemistry, Analytical Chemistry, Environmental Ecotoxicology, or Environmental Toxicology.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Strong interest in experimental and laboratory work.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Knowledge in atmospheric chemistry/air quality would be a plus.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Knowledge in data analysis and statistical processing (e.g., R, Igor Pro).<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Autonomy, scientific rigor, adaptability, teamwork, open-mindedness, analytical skills, and writing abilities.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">• Good oral and written English skills.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="background:yellow;mso-highlight:yellow"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-US">Application procedure<o:p></o:p></span></u></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">The application (before end of September 2024) must include: a CV, the grades obtained in the M2, a letter describing your motivation and your interest in working on the proposed subject and possibly, one or more letters
of recommendation from your current or past teachers and/or supervisors.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Aptos",sans-serif"><o:p> </o:p></span></p>
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